2 Chainz aka Tity Boi hails from Georgia.  He formed the hip hop duo Playaz Circle in College Park in 1997 with his high school friend Earl Conyers (known as Dolla Boy) while he began to adopt "Tity Boi" as his stage name.  Following the release of an independent album titled United We Stand, United We Fall, the duo were introduced to fellow Atlanta rapper Ludacris, when he moved into their College Park apartment complex whilst he was acting as a DJ. After taking interest in Playaz Circle, Ludacris began to record several songs with the group, playing some of them on his radio station.

Ludacris soon become one of the highest-selling rappers in the Southern United States. After hearing of their situation, Ludacris requested of Epps that the duo join his newly formed record label Disturbing Tha Peace, a subsidiary of Def Jam Recordings. Epps agreed to sign, although Conyers did not officially join the label until his mother regained her health, a year after the initial signing.

Their debut album Supply & Demand, was released on October 30, 2007. The lead single and their debut single, "Duffle Bag Boy", became an urban hit single. The song features Lil Wayne, and was performed by the duo at the BET Hip Hop Awards. The duo released their second studio album Flight 360: The Takeoff, in September of 2009.  In January 2010, Playaz Circle filmed a music video for their single "Big Dawg" featuring Lil Wayne and Birdman at Studio Space Atlanta.  Shortly afterwards, Epps left Disturbing tha Peace, a move he claimed was taken in order to advance his career. Although Ludacris was initially reluctant to allow Epps to leave the label, he eventually accepted the decision.

Throughout Epps' career, critics and fans alike have speculated the pseudonym "Tity Boi" was meant to be derogatory towards women, although he repeatedly denied such accusations.  In early 2011, Epps decided to change his stage name to 2 Chainz as he perceived it to be more "family friendly". Following his name change, Epps released a mixtape entitled T.R.U. REALigion, which became his first mixtape to appear on the music charts, peaking at number 58 on the US Billboard Top R&B/Hip-Hop Albums chart. Since the success of his most recent mixtape, Epps has made numerous guest appearances on tracks by prominent recording artists such as, Kanye West's single "Mercy" and Nicki Minaj's "Beez in the Trap". The clean versions of "Got One", "K.O." "Riot" and "Money Making Mission" are featured on DJ Angry's compilation "Tha Clean Versions Vol. 1". "No Lie" is also included.